Currently californium is synthesized by bombarding the element curium with alpha particles. The alpha particles contain two protons and two neutrons in a compound that resembles the nucleus of helium; these particles are created through the alpha decay process of such elements as uranium and radium. Isotopes of californium can be created by using intense neutron radiation on an element such as berkelium; this procedure has to be carried out in a nuclear reactor. Some compounds of californium that have been isolated include californium oxychloride, californium oxide, and californium trichloride. The californium (III) cation has been shown to be stable in aqueous solutions. Californium was first synthesized in a cyclotron at Berkeley; the process consisted of bombarding the 242-isotope of curium with alpha particles; this process produced an isotope of californium, number 245, that had a half life of 44 minutes. While this synthesis processes are effective at producing californium, it is currently not produced on a large scale as it is too expensive, ($27 million per gram), and hazardous.